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Description
MAP2 Recombinant Rabbit mAb (SDT-2060-28)Product Specification Host Rabbit Antigen MAP2 Synonyms Microtubule associated protein 2; MAP 2 Immunogen Recombinant Protein Location Cytoplasm, Cytoskeleton Accession P11137 Clone Number S 2060 28 Antibody Type Recombinant mAb Isotype IgG Application IHC P, IF Reactivity Hu, Ms, Rt Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA, 0. 03% Proclin 300
Product Specification
| Host | Rabbit |
| Antigen | MAP2 |
| Synonyms | Microtubule-associated protein 2; MAP-2 |
| Immunogen | Recombinant Protein |
| Location | Cytoplasm, Cytoskeleton |
| Accession | P11137 |
| Clone Number | S-2060-28 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | IHC-P, IF |
| Reactivity | Hu, Ms, Rt |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| IHC-P | 1:1000 | Hu, Ms, Rt |
| IF | 1:500 | Hu, Ms, Rt |
Background
Microtubule-associated protein 2 (MAP2) is a neuronal protein that plays a crucial role in the development and maintenance of the nervous system. It is primarily found in the dendrites and cell bodies of neurons, where it helps to stabilize and organize microtubules, which are essential components of the cytoskeleton. This stabilization is vital for maintaining the structural integrity of neurons and facilitating the transport of various molecules and organelles within the cell. MAP2 is also involved in synaptic plasticity, the ability of synapses to strengthen or weaken over time, which is a key process in learning and memory. Additionally, it has been implicated in various neurodegenerative diseases, as alterations in MAP2 levels or function can lead to neuronal dysfunction and cell death. Its expression is often used as a marker for neuronal differentiation and maturation in research settings.
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