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Description
BSEP Recombinant Rabbit mAb (SDT-045-13)Product Specification Host Rabbit Antigen BSEP Synonyms Bile salt export pump, ATP binding cassette sub family B member 11, ABCB11 Immunogen Synthetic Peptide Location Cell membrane Accession O95342 Clone Number SDT 045 13 Antibody Type Rabbit mAb Application IHC P, IF Reactivity Hu Purification Protein A Concentration 0. 25 mg ml Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA, 0. 03% Proclin 300 Stability & Storage 12 months
Product Specification
| Host | Rabbit |
| Antigen | BSEP |
| Synonyms | Bile salt export pump, ATP-binding cassette sub-family B member 11, ABCB11 |
| Immunogen | Synthetic Peptide |
| Location | Cell membrane |
| Accession | O95342 |
| Clone Number | SDT-045-13 |
| Antibody Type | Rabbit mAb |
| Application | IHC-P, IF |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 0.25 mg/ml |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| IHC-P | 1:1000 | |
| IF | 1:1000 |
Background
The bile salt export pump BSEP is critically involved in secretion of bile salts into bile. Its function can be disturbed or abolished by inherited mutations. This will lead to progressive intrahepatic cholestais and severe liver disease. In addition to mutations, Bsep can be inhibited by acquired factors such as for example xenobiotics or drugs, aberrant bile salt metabolites or pregnancy. This inhibition will lead to acquired cholestasis. Some drugs are now known to be competitive inhibitors of Bsep. In addition, a polymorphism in the gene coding for Bsep has been identified as a potential susceptibility factor for acquired cholestasis [PMID: 20028269].
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