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Description
Biotinylated IgG1 Fc&Avi Tag Protein, HumanProduct Specification Species Human Synonyms IgG1 Fc, Ig gamma 1 chain C region, IGHG1 Accession P01857 1 Amino Acid Sequence Pro100 Lys330, with C Avi tag and IgG1 Fc Expression System HEK293 Molecular Weight 30kDa (Reducing) Purity 95% by SDS PAGE Endotoxin <0. 1EU g Conjugation Biotin Tag Avi Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4. Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water
Product Specification
| Species | Human |
| Synonyms | IgG1 Fc, Ig gamma-1 chain C region, IGHG1 |
| Accession | P01857-1 |
| Amino Acid Sequence | Pro100-Lys330, with C-Avi tag and IgG1 Fc |
| Expression System | HEK293 |
| Molecular Weight | 30kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Biotin |
| Tag | Avi Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4. |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1. Peter Sondermann, Robert Huber, Vaughan Oosthuizen & Uwe Jacob: The 3.2-Å crystal structure of the human IgG1 Fc fragment–FcγRIII complex. Nature volume 406, pages267–273 (2000). |
Background
Immunoglobulin G (IgG) is a monomer immunoglobulin, mainly involved in Immunoglobulin G (IgG) is a monomer immunoglobulin, mainly involved in secondary antibody reaction, plasma B cell synthesis and secretion, constitute 75% of human serum immunoglobulin. There are four subtypes of human IgG antibodies: IgG1, IgG2, IgG3, IgG4; mice IgG can be divided into five subtypes; IgG1, IgG2A, IgG2B, IgG2C and IgG3; rats have four subtypes: IgG1, IgG2A, IgG2B and IgG2C. The nomenclature of IgG subtypes of different species is independent, so there is no correlation among different genera. The content of IgG1 in serum accounts for about 60%, and the half-life in serum is about 21 days. After pepsin cleavage, IgG1 is divided into two antigenic binding sites F (ab) s and a highly conserved Fc fragment, and Fc has a highly conserved N-glycosylation site. IgG1 is the most potential subtype in tumor immunotherapy. The active form of IgG1 is bivalent monomer, and human IgG1 can also bind to mouse Fc γ receptor, so the obvious effect can be observed in mouse model.
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