Shipping Estimate
USA
- USA
- CAN
- USA
- CAN
Ships within 48 hours · Estimated delivery Jul 12 - Jul 17
Promo Codes Available:
For Your Every Summer RSVP, with Code: SUMMER15
Description
PAD4 Recombinant Rabbit mAb (SDT-2416-3)Product Specification Host Rabbit Antigen PAD4 Synonyms Protein arginine deiminase type 4; Peptidylarginine deiminase IV; Protein arginine deiminase type IV; Pad4; Pdi4; Padi4 Immunogen Synthetic Peptide Location Cytoplasm, Nucleus Accession Q9Z183 Clone Number SDT 2416 3 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Ms, Rt Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid
Product Specification
| Host | Rabbit |
| Antigen | PAD4 |
| Synonyms | Protein-arginine deiminase type-4; Peptidylarginine deiminase IV; Protein-arginine deiminase type IV; Pad4; Pdi4; Padi4 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Nucleus |
| Accession | Q9Z183 |
| Clone Number | SDT-2416-3 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Ms, Rt |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Ms |
| IHC-P | 1:500-1:1000 | Ms, Rt |
Background
Protein-arginine deiminase type-4 (PAD4) is a human enzyme encoded by the PADI4 gene, located on the short arm of chromosome 1. PAD4 is a calcium-dependent enzyme that catalyzes the conversion of arginine residues to citrulline in proteins, a process known as citrullination. It is primarily expressed in white blood cells such as granulocytes and monocytes, and can also be found in the nucleus. PAD4 plays a crucial role in the formation of neutrophil extracellular traps (NETs), which are involved in the immune response against pathogens. However, excessive PAD4 activity and NET formation have been implicated in various diseases, including rheumatoid arthritis, multiple sclerosis, cancer, and cardiovascular diseases. PAD4 also influences gene expression by deimininating histones, and its dysregulation can impact cellular processes like apoptosis and differentiation. Due to its involvement in multiple disease pathways, PAD4 has become a promising target for therapeutic interventions.
Shipping Notes
- Free Standard Shipping on $100+ Orders to the USA.
- Except Preorder products are shipped in 48 hours.
- Delivery to the USA:
- Standard Shipping : 3-10 business days
- If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
- Final sale items are not eligible for returns or exchanges.
- To process your return/exchange, please contact us at [email protected]
- Please click here for more details>>> Return & Exchange Policy